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Thromb Haemost 1971; 26(01): 015-021
DOI: 10.1055/s-0038-1653651
DOI: 10.1055/s-0038-1653651
Originalarbeiten – Original Articles – Travaux Originaux
An Intrinsic Blood Platelet Abnormality in an Homocystinuric Boy, Corrected by Pyridoxine Administration
This work was supported by a Training Grant from the Children’s Bureau, Department of Health Education and Welfare and by a Grant No. 2M01-FR-42 from the Clinical Research Centers Branch, Division of Research Resources, National Institutes of Health, and by a grant from the Michigan Heart Association.
Further Information
Publication History
Publication Date:
24 July 2018 (online)
Summary
Platelet aggregation in a boy with homocystinuria (HCU) was compared to that found in normal subjects. Response to adenosine diphosphate (ADP) was diminished while aggregation with collagen and adrenalin was normal. The impaired response to ADP was not corrected by resuspension of HCU platelets in normal plasma or by a period of therapy with a low protein diet, but it was enhanced promptly with pyridoxine 750 mg/day. The increase of platelet sensitivity to ADP during B6 administration could not be correlated with plasma concentrations of either homocystine or methionine.
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